Chronic obstructive pulmonary disease and newly diagnosed tuberculosis: factors influencing outcome of the pathological process


DOI: https://dx.doi.org/10.18565/pharmateca.2018.13.44-50

N.V. Bagisheva (1), V.V. Goltyapin (2), A.V. Mordyk (1), D.I. Mordyk (3)

1) Omsk State Medical University, Omsk, Russia; 2) Sobolev Institute of Mathematics of the SB RAS, Novosibirsk, Russia; 3) FGI MB of MSA for the Omsk Region of the Ministry of Labor of Russia, Omsk, Russia
Background. The combination of chronic obstructive pulmonary disease (COPD) and tuberculosis (TB) is associated with the presence of common risk factors for the development of both diseases: smoking, smoke, industrial aeropollutants, low socioeconomic status; and each of them has an adverse impact on the course of the pathological process. OIbjective. Evaluation of the effect of various factors on the results of treatment of newly diagnosed TB in COPD patients. Methods. A simple retrospective study with participation of 514 patients was performed. Using the methods of mathematical statistics, the degree of influence of risk factors on the outcome of TB in patients with combined pathology was determined. Results. Likelihood of an unfavorable outcome is higher in case of combination of TB with COPD, the than for isolated TB (17.2 vs. 4.5%). The presence of smoking and smoking more than 20 cigarettes a day significantly increase the risk of an unfavorable outcome of TB in COPD patients. According to the ANOVA results, the factor «number of smoking years» – 23% in the total sum of the influence of all factors, high CAT-test scores –15.6%, visual analog scale – 4.2%. The cumulative effect of the trigger (smoking years–dyspnoea–CAT-test) on the outcome was 29.8% compared to the isolated effect of the signs studied.
Conclusion. The use of the obtained data will allow predicting the possible outcome of TB in COPD patients, which will determine timely correction of therapy of combined pathology to improve prognosis, reduce disability and mortality.
Keywords: tuberculosis, chronic obstructive pulmonary disease, risk factors

About the Autors


Corresponding author: Natalia V. Bagisheva, PhD, Teaching Assistant of the Department of Internal Diseases and Outpatient Therapy, Omsk State Medical University, Omsk, Russia; e-mail: ppi100@rambler.ru
Address: 12, Lenin Street, Omsk, 644099 Russian Federation


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