Masks of gastroesophageal reflux disease. Results of 20-year observation


DOI: https://dx.doi.org/10.18565/pharmateca.2018.13.30-43

I.V. Mayev, A.N. Kazyulin, G.L. Yurenev, E.S. Vyuchnova, E.G. Lebedeva, D.T. Dicheva, G.A. Busarova

Department of Propaedeutics of Internal Diseases and Gastroenterology of the Moscow Medical Stomatological University n.a. A.I. Evdokimov, Moscow, Russia
The article represents a review of 20-year study of clinical manifestations of gastroesophageal reflux disease (GERD), conducted with the participation of the staff of the department. It was established that cardiac syndrome of GERD is detected in 78.8% of patients without background cardiac pathology. The main manifestations of this syndrome include retrosternal pain, cardialgia, psycho-vegetative dysfunction, violations of the function of automatism, conductivity, excitability. Disturbances in rhythm and conductivity in patients with «nocturnal acid breakthroughs» can be considered as the factors for the development of prognostically severe and fatal arrhythmias. GERD was detected in 53.1% of the examined patients suffering from bronchial asthma. There was a positive correlation between the severity of the course of bronchial asthma and the severity of the clinical signs of GERD. It was found that 88.5% of patients with GERD had otorhinolaryngological pathology, and this mask was represented by chronic pharyngitis in the overwhelming majority of cases. It was found that changes in the oral cavity are closely interrelated with the duration of the course and the severity of GERD. The obtained data led to the conclusion that the original rabeprazole is a drug of choice for the treatment of not only GERD, but also the manifestations of its clinical masks, taking into account its high and rapid effectiveness with regard to relief of symptoms of GERD and its masks.
Keywords: gastroesophageal reflux disease, cardiac mask, bronchopulmonary mask, otorhinolaryngological mask, stomatological mask, original rabeprazole

About the Autors


Corresponding author: A.N. Kazyulin, MD, Acad. of RANS, Prof. at the Department of Propaedeutics of Internal Diseases and Gastroenterology MSMSU n.a. A.I. Evdokimov, Moscow, Russia; e-mail: alexander.kazyulin@yandex.ru
Address: 20, Build. 1, Delegatskaya Street, Moscow 127473, Russian Federation


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