FUNCTIONAL DYSPEPSIA AND INTESTINAL MICROBIOTA: IS RELATIONSHIP POSSIBLE?


DOI: https://dx.doi.org/10.18565/pharmateca.2018.13.23-29

M.Yu. Serkova, E.Yu. Pavlova, I.A. Oganezova

Department of Propaedeutics of Internal Diseases, Gastroenterology and Dietology, North-Western State Medical University n.a. I.I. Mechnikov, St. Petersburg
Background. Functional dyspepsia is a widespread disease that has a significant impact on the quality of life of patients; both dysbiotic changes in the intraluminal microbiota and the interaction of the microbiota of the intestinal mucosa with the immunity of the host organism can have significant importance in its pathogenesis. Objective: to reveal the features of intestinal microbiota in patients with functional dyspepsia. Methods. Fecal and blood samples were examined in 70 patients with functional dyspepsia, mean age 44 years. The examination of metabolites of microorganisms was carried out by gas chromatography and mass spectrometry according to G.A. Osipov. Results. In patients with functional dyspepsia, a decrease in the level of bacteria of the genera Bifidobacterim spp., Lactobacterium spp., excessive growth of representatives of the genera Eubacterium spp., Clostridium spp. and Klebsiella spp.,
aerobes of the genus Rhodococcus spp., the tendency to an excessive level of metabolites of fungi has been determined.
Conclusion. The revealed dysbiotic changes in the composition of the luminal and parietal intestinal microbiota can have a significant importance in the pathophysiology of functional dyspepsia. Decrease in the level of anaerobic microorganisms contributes to the deterioration of colonization resistance of intestinal microbiocenosis and increases the risk of colon colonization by pathogenic microbiota, the formation of long-term chronic digestive disorders.
Keywords: functional dyspepsia, intestinal microbiota, mass spectrometry of microbial markers

About the Autors


Corresponding author: Margarita Yu. Serkova, PhD, Teaching Assistant at the Department of Propaedeutics of Internal Diseases of Gastroenterology and Dietology, North-Western State Medical University n.a. I.I. Mechnikov, St. Petersburg, tel. +7 (812) 543-95-38, e-mail: serkova.margarita@yandex.ru, ORCID: https://orcid.org/0000-0001-9600-3131
Address: 41, Kirochnaya Street, St. Petersburg 191015, Russian Federation


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