Multiple myeloma, secondary liver amiloidosis. Description of the clinical case


I.G. Bakulin, I.A. Oganezova, O.I. Medvedeva, V.V. Petrenko, Yu.V. Medvedev

North-Western State Medical University n.a. I.I. Mechnikov, St. Petersburg, Russia
Background. Multiple myeloma, or Rustitzky-Kahler’s disease (a plasma cell malignancy), is a disease of the hematopoietic system related to paraproteinemic leukemia. Secondary systemic amyloidosis is one of the complications of this disease. The article presents the literature data on etiology, pathophysiology, clinical manifestations, diagnosis and treatment options for this pathology.
Description of the clinical case. A description of the clinical case reflecting the course of multiple myeloma complicated by secondary systemic amyloidosis is presented.
Conclusion. Practitioners should pay special attention to the interpretation of data for the evaluation of liver fibrosis obtained by performing non-invasive diagnostic techniques. In the presence of results that contradict each other or significantly differ from each other, it is advisable to recommend a needle liver biopsy.
Keywords: multiple myeloma, liver amyloidosis, systemic amyloidosis, cholestasis, liver fibrosis

About the Autors

Corresponding author: Yury V. Medvedev, Postgraduate Student at the Department of Propaedeutics of Internal Diseases, Gastroenterology and Dietology, North-Western State Medical University n.a. I.I. Mechnikov, St. Petersburg, Russia; e-mail:
Address: 41, Kirochnaya Street, St. Petersburg, 191015 Russian Federation

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