POTENTIALS FOR THE OPTIMIZING THE CONTROL OF BRONCHIAL ASTHMA: SMALL AIRWAYS AND EXTRA-FINE-DISPERSED FORMS OF INHALERS


DOI: https://dx.doi.org/10.18565/pharmateca.2018.8.49-57

A.I. Sinopalnikov, Yu.G. Belotserkovskaya, A.G. Romanovsky

Russian Medical Academy of Continuous Professional Education, Moscow, Russia
Clinical practice shows that adequate control of bronchial asthma (BA) is absent in more than 50% of patients. The cause of unsatisfactory BA control may be insufficient suppression of inflammation in the respiratory tract, including distal airways. Inhalation therapy remains the leading method of treatment of BA. One of the important properties of the inhaled medication, which determines the seve-rity of its anti-inflammatory and bronchodilating action, is the level of deposition in the airways. To achieve small airways, «responsible» for an insufficient level of control in certain BA phenotypes, it is necessary to use drugs, including combined drugs, containing extra-fine dispersed aerosol forms. During the last decade, a significant database on the positive effects of beclomethasone dipropionate/
formoterol (BDP/F) on everyday BA symptoms, respiratory function, and the frequency of exacerbations has been accumulated. Currently, the evaluation of the effectiveness of BDP/F continues primarily in those groups of patients with asthma, where the impact of the pathology of small airways can adversely affect the ability to achieve control: in smokers, in patients with a long history of asthma, in patients with detected «air trapping» phenomenon. BDP/F provides the most significant effect, incl. pronounced reducing the frequency of exacerbations, specifically in such patients.
Keywords: bronchial asthma, bronchial asthma control, small airways, extra-fine-dispersed aerosol, combined therapy of bronchial asthma, beclomethasone dipropionate/formoterol

About the Autors


Corresponding author: Yu.G. Belotserkovskaya – PhD, Associate Professor at the Department of Pulmonology, Russian Medical Academy of Continuous Professional Education, Moscow, Russia; e-mail: belo-yuliya@yandex.ru


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