EVALUATION OF PARADONTAL MICROBIOME IN PATIENTS WITH FUNCTIONAL DISPEPSIA


DOI: https://dx.doi.org/10.18565/pharmateca.2018.2.58-63

R.A. Aivazova (1), A.K. Kuliyeva (1), A.A. Samsonov (1), A.B. Shevelev (2)

1) Moscow State Medical Stomatological University n.a. A.I. Evdokimov, Moscow, Russia; 2) Institute of Biochemical Physics n.a. N.M. Emanuel, Moscow, Russia
Purpose of this study was the evaluation of the role of antagonistic relationships between the components of periodontal microbiocenosis, aimed at finding potential parodontoprotectors, as well as assessing the effect of functional dyspepsia (FD) on its composition. Material and Methods. According to real-time polymerase chain reaction (PCR-RV), sample data from 155 patients with or without parodontal pathology and dyspeptic syndrome were analyzed. Parallel measurement of the representation of periodontopathogens and periodontoprotectors in the microbiota allows to achieve the greatest effectiveness in the diagnosis of periodontitis. Tanerella forsythia, Porphyromonas gingivalis and Treponema denticola species have the most significant correlation with the severity of chronic periodontitis in patients with FD. Statistically significant gender differences in the content of parodontopathogenic bacteria and potential parodontoprotectors in soft calcular deposit of diseased and healthy people are shown for the first time. Conclusions. The approach described in the article can be used to determine the cause of periodontitis in patients with FD, the risk of concomitant pathology in the future and the effectiveness of its treatment. The complex of additional methods of examination of patients with FD should include examination of the oral cavity and microflora of periodontal pockets using methods of molecular diagnostics, because the constant presence of parodontopathogens in periodontal tissues can significantly worsen the quality of life of patients with combined pathology.
Keywords: microbiome, periodontium, oral cavity, functional dyspepsia, periodontitis, real-time polymerase chain reaction, Dentoflor, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tanerella forsythia, Treponema denticola, Veillonella parvula and Streptococcus sanguinis

About the Autors


Corresponding author: R.A. Aivazova – PhD, Teaching Assistant at the Department of Periodontology of the Stomatological Faculty, Moscow State Medical Stomatological University n.a. A.I. Evdokimov, Moscow, Russia; e-mail: a_reg@mail.ru


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