NON-DRUG METHODS IN THE TREATMENT OF CHILDREN WITH ATOPIC BRONCHIAL ASTHMA


DOI: https://dx.doi.org/10.18565/pharmateca.2018.1.48-52

E.G. Asiryan

Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Belarus
Purpose. To evaluate the clinical and immunological efficacy of use of ultrasound in combination with autoserotherapy in children with atopic bronchial asthma (BA). Material and Methods. The study included 64 children with atopic asthma aged 6 to 18 years. Group A received ultrasound in combination with autoserotherapy in addition to the background therapy. Group B received background therapy only. During the study, the level of disease control, the use of background therapy, and basophil phenotypes were assessed. Results. In both groups, the disease control has increased in children aged over 12 years; the results of the ACT test at 1 and 3 months were significantly higher in Group A than in Group B (P <0.05). When comparing the results of the test in children aged 6-12 years, the results of the C-ACT test at 1 month were statistically significantly higher in Group A than in Group B (P <0.05), indicating an earlier achievement of control in the group of children who received ultrasound with autoserotherapy in addition to background therapy. After 6 months from the start of treatment, the number of children in need of background therapy was significantly higher in Group B than in Group A (P <0.05). When studying the basophil phenotypes, it was found that in patients receiving ultrasound with autoserotherapy, the relative and absolute levels of basophils carrying CD203c +, CD203c+CD63 + receptor have decreased. In this group of children, the absolute level of CD203c+IgE+ basophils was statistically significantly lower (P <0.05). When comparing the parametres in two groups, it was revealed that the relative level of CD203c + CD63 + basophils was statistically significantly lower in group A than in group B at 82-90 days (P <0.05). Conclusions. The use of ultrasound in combination with autoserotherapy in children with atopic BA contributes to a faster achievement of disease control, shorter use of background therapy, and changes the basophil phenotype, reducing proallergic indicators.
Keywords: bronchial asthma, basophils, ultrasound, autoserotherapy

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Corresponding author: E.G. Asiryan – PhD, Associate Professor at the Department of Pediatrics, Vitebsk State University, Vitebsk, Belarus; e-mail: lena.asiryn@mail.ru


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