THE USE OF STATINES IN PATIENTS WITH ARTERIAL HYPERTENSION AND CHRONIC HEART FAILURE WITH PRESERVED LEFT VENTRICULAR EJECTION FRACTION


S.G. Kanorsky, A.F. Sereda

Department of Therapy № 2 of the Faculty of Continuing Education and Professional Retraining of Specialists FSBEI HE “Kuban State Medical University” of RMH, Krasnodar
The prospective randomized trial included 167 patients with chronic heart failure (CHF) of II-III functional classes with preserved left ventricular ejection fraction (LVEF) against the background of III stage arterial hypertension. In addition to antihypertensive therapy with perindopril and verapamil SR (n=85) or amlodipine (n=82), atorvastatin was prescribed, which was regularly taken by 50.6 and 48.8% of patients, respectively. After 12 months, in each treatment group, the clinical status and quality of life improved, and the distance covered in the 6-minute walk test increased. Patients receiving atorvastatin had significantly reduced N-terminal pro-brain natriuretic peptide levels; there was a tendency to improvement of diastolic LV function. Addition of atorvastatin to the treatment of CHF with preserved LVEF is advisable in connection with the potential opportunity to improve the prognosis of patients.

About the Autors


Corresponding author: S.G. Kanorsky – MD, Prof., Head of the Department of Therapy № 2 FCEPRS FSBEI HE «Kuban State Medical University»
of RMH, Krasnodar; e-mail: kanorskysg@mail.ru


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