IMMUNOLOGICAL FEATURES OF VIRAL INTESTINAL INFECTIONS IN CHILDREN


K.D. Ermolenko (1, 2), L.B. Kulyashova (1), N.G. Roschina (1), D.K. Ermolenko (1), I.V. Razdjakonova (1), N.V. Gonchar (1, 3)

1) FBIS “St. Petersburg SRI of Epidemiology and Microbiology n.a. Pasteur” of RMH, St. Petersburg; 2) FSBI “Children’s Scientific and Clinical Center of Infectious Diseases” of the Federal Medical Biological Agency, St. Petersburg; 3) North-West State Medical University n.a. I.I. Mechnikov, St. Petersburg
The article presents the results of evaluation of features of the immunological parameters in 41 children in the acute period and during period of recovery after norovirus, rotavirus and combined rotavirus-norovirus infections. It has been shown that various components response participate in the immune response in viral intestinal infections, and their roles vary depending on the period of the infectious process. The acute period of intestinal infection is characterized by an increase in the interferon-γ levels, as well as a decrease in the average content of T-helpers and cytotoxic lymphocytes, more pronounced in rotavirus than in norovirus infection. During the period of recovery, normalization of the level of the main subpopulations of lymphocytes and interferon status are noted, against a background of moderate increase in mature B-lymphocytes and serum immunoglobulin A levels, which reflects the involvement of the immune system in the antiviral response.

About the Autors


Corresponding author: K.D. Ermolenko – full-time postgraduate student, Junior Researcher at the Department of Identification of Pathogens FSBI «Children’s Scientific and Clinical Center of Infectious Diseases» of the Federal Medical Biological Agency, FBIS «St. Petersburg SRI of Epidemiology and Microbiology n.a. Pasteur» of RMH, St. Petersburg; e-mail: ermolenko.kd@yandex.ru


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