MOLECULAR FUNCTIONS OF MAGNESIUM-DEPENDENT MYOCARDIAL PROTEINS INDICATE PROSPECTS FOR USE OF MAGNESIUM OROTATE PREPARATIONS IN CARDIOLOGICAL PRACTICE


I.Yu Torshin (1), O.A. Gromova (2)

(1) FSAEI HPE "Moscow Institute of Physics and Technology", Dolgoprudny; (2) SBEI HPE "Ivanovo State Medical Academy" of RMPH, Ivanovo
The article presents modern data on the regulatory effect of magnesium on the cardiovascular system. Cardioprotective effects of magnesium are substantiated. Significance of magnesium-dependent proteins, supporting the function of the myocardium, is considered. The best ways to correct magnesium deficiency, particularly in cardiac patients, are discuss. The use of second generation magnesium preparations, containing organic magnesium salts with high bioavailability, is most promising. Magnerot - magnesium salt and orotic acid – is one of such drugs. The efficiency of magnesium orotate in conditions with magnesium deficiency, especially in patients undergoing coronary surgery, is demonstrated. The drug has antiarrhythmic, vasodilating and cardioprotective effects. Increasing myocytes resistance to ischemia, magnesium orotate has positive effect on the clinical course of myocardial infarction and heart failure. Orotate magnesium is also effective in idiopathic mitral valve prolapse

About the Autors


O.A. Gromova – MD, Prof. at the Department of Pharmacology and Clinical Pharmacology SBEI HPE IvSMA of RMPH, Ivanovo; tel.8 (4932) 41-65-25; e-mail: unesco.gromova@gmail.com


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