POTENTIALS FOR THE NEUROPROTECTION OF POSTOPERATIVE COGNITIVE DYSFUNCTION AFTER CORONARY BYPASS SURGERY: RESULTS OF SIX-MONTH FOLLOW-UP


M.M. Petrova (1), S.V. Prokopenko (2), O.V. Eremina (1), E.Yu.Mozheyko (2), M.I.Gankin (3), D.S. Kaskaeva (1)

(1) Department of policlinic therapy, family medicine and healthy lifestyle with the course of PO SBEI HPE "Krasnoyarsk State Medical University n.a. V.F. Voyno-Yasenetsky" of RMPH, Krasnoyarsk; (2) Department of nervous diseases with a course of medical rehabilitation SBEI HPE "Krasnoyarsk State Medical University n.a. V.F. Voyno-Yasenetsky" of RMPH, Krasnoyarsk; (3) FSBI "Federal Center for Cardiovascular Surgery" of RMPH, Krasnoyarsk
The article presents the analysis of cognitive impairment in 60 patients with coronary artery disease in the early postoperative period and 6 months after coronary artery bypass surgery. Patients were divided into 2 equal groups (30 subjects). The main group has received citicoline (Ceraxon) as cerebral neuroprotective agent intravenously one day before surgery at a dose of 1000 mg dissolved in 200 ml of 0.9% NaCl, then for 7 days after surgery, followed by oral administration of the drug at a dose of 900 mg/day for 2 months. Comparison group has not received neuroprotective agents in perioperative period. Against the background of treatment with citicoline, the main group has shown persistence of pre-operative level of cognitive functioning according test results, even with improvements in some tests related to subcortical-frontal dysfunction. Comparison group has shown a significant decrease from baseline in cognitive functioning 8-10 days after the surgery, which lasted for a long time. The results allow to consider citicoline (Ceraxon) as a protector of postoperative cognitive dysfunction. It is possible to recommend the inclusion of the drug in the standard scheme of preoperative preparation, and its use in the early postoperative period.

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About the Autors


M.M. Petrov – Doctor of Medical Sciences, Prof., Head of the Department of policlinic therapy, family medicine and healthy lifestyle with the course of PO SBEI HPE "Krasnoyarsk State Medical University n.a. V.F. Voyno-Yasenetsky" of RMPH, Krasnoyarsk; e-mail: stk99 @ yande
S.V. Prokopenko - Doctor of Medical Sciences, Prof., Head of the Department of nervous diseases with a course of medical rehabilitation SBEI HPE "Krasnoyarsk State Medical University n.a. V.F. Voyno-Yasenetsky" of RMPH, Krasnoyarsk; e-mail: s.v.proc.58@mail.ru
O.V. Eremina – PhD in Medical Sciences, doctoral student at the Department of policlinic therapy, family medicine and healthy lifestyle with the course of PO SBEI HPE "Krasnoyarsk State Medical University n.a. V.F. Voyno-Yasenetsky" of RMPH, Krasnoyarsk; e-mail: eryomina @ mail.ru
E.Yu. Mozheyko - Doctor of Medical Sciences, Associate Professor, Department of nervous diseases with a course of medical rehabilitation SBEI HPE "Krasnoyarsk State Medical University n.a. V.F. Voyno-Yasenetsky" of RMPH, Krasnoyarsk, Head of the Office of Stroke Prevention, Diagnosis of Cognitive Impairment SCC FMBA of Russia; e-mail: el_mozhejko@mail.ru
M.I. Gankin - PhD in Medical Sciences, Head of the Department of Functional Diagnostics FSBI "Federal Centre for Cardiovascular Surgery" of RMPH, Krasnoyarsk
D.S. Kaskaeva- PhD in Medical Sciences, Assistant Professor at the Department of policlinic therapy, family medicine and healthy lifestyle with the course of PO SBEI HPE "Krasnoyarsk State Medical University n.a. V.F. Voyno-Yasenetsky" of RMPH, Krasnoyarsk; e-mail: Dashakas.ru@mail.ru


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