A.A. Zajcev, A.V. Vlasova

The first MSMU n.a. I.M. Sechenov, Moscow
This paper reviews the etiology, diagnosis, and treatment of acute respiratory viral infections (ARVI). Today there are a number of challenging problems of ARVI pharmacotherapy. Firstly, an effective causative treatment is possible only for influenza infection. Secondly, diversity of clinical manifestations of ARVI (fever, headache, weakness, runny nose, cough, etc.) requires concurrent administration of multiple medications of different pharmacological groups. And finally, difficulties in differentiating viral and bacterial infections have led to excessive administration of antibacterial drugs thus giving rise to emergence and ongoing spread of antimicrobial-resistant pathogens. An attractive alternative for ARVI patient presenting with several symptoms is the use of combined drugs. The ability to simultaneously relieve multiple symptoms of viral infection has brought about extraordinary popularity of these drugs.


  1. Gwalthey J. The common gold. In: G.L. Mandell, J.F. Bennet, R. Dolin, eds. Principles and practice of infectious diseases, 5th edn. Philadelphia: Churchill Livingstone, 2000. P. 651–65.
  2. Allen P., Simenson S. Management of common cold symptoms with over-the-counter medications: clearing the confusion. Postgrad. Med. 2013;125(1):73–81.
  3. Бартлетт Дж. Инфекции дыхательных путей. Пер. с англ. М., 2000. 192 с.
  4. Синопальников А.И. Простуда. В кн.: Внебольничные инфекции дыхательных путей. М., 2007. С. 131–44.
  5. Nicholson K.G. Managing influenza in primary care. Blackwell Science, 1999. 106 p.
  6. Jefferson T., Demicheli V., Rivetti D., Jones M., Di Pietrantonj C., Rivetti A. Antivirals for influenza in healthy adults: systematic review. Lancet. 2006;367(9507):303–13.
  7. Jefferson T., Demicheli V., Deeks J., Rivetti D. Neuraminidase inhibitors for preventing and treating influenza in healthy adults (Cochrane Review). In: The Cochrane Library. Oxford: Update Software, 2003.
  8. Mandell L., Wunderink R., Anzueto A., Bartlett J.G., Campbell G.D., Dean N.C., Dowell S.F., File T.M.Jr., Musher D.M., Niederman M.S., Torres A., Whitney C.G.; Infectious Diseases Society of America; American Thoracic Society. Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in Adults. Clin. Infect. Dis. 2007;44(2):27–72.
  9. Чучалин А.Г., Синопальников А.И., Козлов Р.С. и др. Клинические рекомендации по диагностике, лечению и профилактике тяжелой внебольничной пневмонии у взрослых. М., 2014. 82 с.
  10. Taverner D., Latte G. Nasal decongestants for the common cold. Cochrane Database. Syst. Rev. 2009;2:CD001953. doi: 10.1002/14651858.CD001953.
  11. Sutter A., Lemiengre M., Campbell H., Mackinnon H. Antihistamines for the common cold. Cochrane Database Syst. Rev. 2003;3: CD001267. doi: 10.1002/14651858. CD001267.
  12. Hayward G., Thompson M., Perera R., Del Mar C.B., Glasziou P.P., Heneghan C.J. Corticosteroids for the common cold. Cochrane Database Syst. Rev. 2012;8:CD008116. doi: 10.1002/14651858.CD008116.
  13. De Sutter A., van Driel M., Kumar A., Les-slar O., Skrt A. Oral antihistamine-decongestant-analgesic combinations for the common cold. Cochrane Database Syst. Rev. 2012;2:CD004976. doi: 10.1002/14651858. CD004976.
  14. Зайцев А.А. Острые респираторные вирусные инфекции: преимущества комбинированных препаратов. Лечащий врач. 2008;2:78–9.
  15. Жаркова Н.Е. Симптоматическое лечение ОРВИ: будущее за комбинированными препаратами. РМЖ. 2007;22:1636.
  16. Доступно на:

About the Autors

A.A.Zaitsev – Doctor of Medical Sciences, SBEI HPE «First MSMU n.a. I.M. Sechenov» of RMPH, Moscow; tel. 8 (499) 263-10-47
A.V. Vlasova – PhD in Medical Sciences, SBEI HPE «First MSMU n.a. I.M. Sechenov» of RMPH, Moscow

Similar Articles

Бионика Медиа