COMBINATION THERAPY WITH GLIMEPIRIDE AND METFORMIN IN PATIENTS WITH TYPE 2 DIABETES MELLITUS. THE RESULTS OF OBSERVATIONAL STUDIES


N.V. Zaitseva, M.Sh. Shamkhalova

Department of diabetic nephropathy and haemodialysis FSBI "Endocrinological Research Center" of RMPH, Moscow
Lifestyle modification, which is the first step in the treatment of type 2 diabetes mellitus, even in case of simultaneous beginning of therapy with metformin, often does not lead to the achievement of compensation of carbohydrate metabolism. Glimepiride, a representative of the third generation sulfonylureas, is one of the drugs of choice for the enhancement of antihyperglicemic therapy. The article presents the results of open multicenter observational studies on the efficacy and safety of combined use of metformin and glimepiride. Combination treatment with metformin and glimepiride allows to significantly improve the status of carbohydrate metabolism in patients with type 2 diabetes mellitus. This therapy is safe due to the low risk of hypoglycaemia, lack of side effects and adverse effects on body weight.

About the Autors


N.V. Zaitseva – PhD in Medical Sciences, Senior Scientist at the Department of diabetic nephropathy and haemodialysis FSBI "Endocrinological Research Center" of RMPH, Moscow; e-mail: nata.zaec@gmail.com
M.Sh. Shamhalova – MD, head of the Department of diabetic nephropathy and haemodialysis FSBI "Endocrinological Research Center" of RMPH, Moscow


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