ANALYSIS OF THE EFFICACY AND SAFETY OF DOMESTIC INSULIN NPH RINSULIN IN NIZHNY NOVGOROD


O.V. Zanozina, Yu.A. Sorokina, L.V. Lovtsova, N.N. Borovkov

VSEI HPE NizhSMA of RMPH, Nizhny Novgorod
The article presents the results of the study aimed to the evaluation of the efficacy and safety of insulin isophane Rinsulin NPH (n = 23) and Humulin NPH (n = 14) in 37 patients with diabetes mellitus (DM) type 2, in which previous therapy with oral hypoglycemic agents in the maximum doses was ineffective. The data obtained suggest that there were no significant differences in the effects of Rinsulin NPH and Humulin NPH in patients with DM 2 during insulin therapy for 8 weeks. Therapy with Rinsulin NPH do not lead to the weight gain unlike Humulin NPH. These drugs can be used for initiating insulin therapy in patients previously not treated with insulin, and also for replacement of other insulin preparations, if necessary. In case of transfer from other brands of insulin to Rinsulin NPH, the use of same doses and regimens with subsequent correction of the results by self-control can be recommended, as in other cases of replacement of insulin preparations.

About the Autors


O.V. Zanozina – MD, Prof. at the Department of Hospital Therapy NizhSMA, Nizhny Novgorod; e-mail: zwx2@mail.ru
Yu.A. Sorokina – postgraduate student at the Department of General and Clinical Pharmacology NizhSMA, Nizhny Novgorod
L.V. Lovtsova – MD, Prof., Head of the Department of General and Clinical Pharmacology NizhSMA, Nizhny Novgorod
N.N. Borovkov – MD, Prof. Head of the Department of Hospital Therapy NizhSMA, Nizhny Novgorod


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