ADIPONECTIN, LEPTIN, AND OTHER METABOLIC PARAMETERS IN PATIENTS WITH HYPOTHYROIDISM


N.I. Verbovaya,I.Yu. Kapralova, A.F. Verbovoy

Department of Endocrinology SBEI HPE Samara State Medical University of RMPH, Samara
The article presents the results of evaluation of the relationship of adiponectin, leptin, and hormonal-metabolic parameters based on the survey of 93 women with hypothyroidism. In patients with hypothyroidism, insulin resistance and compensatory hyperinsulinemia were identified. They also have pronounced atherogenic dyslipidemia, which was expressed by elevated levels of total cholesterol, triglycerides, low density lipoprotein cholesterol, and atherogenic index, and decreased level of high density lipoprotein cholesterol. In women with hypothyroidism, concentration of leptin was increased and adiponectin levels were reduced. It is obvious that changes of these adipokines play a role in the development of atherogenic dyslipidemia.

About the Autors


N.I. Verbovaya - Department of Endocrinology SBEI HPE Samara State Medical University of RMPH
I.Y.Kapralova - Department of Endocrinology SBEI HPE Samara State Medical University of RMPH
A.F.Verbovoy – MD, Prof., Head of the Department of Endocrinology SBEI HPE Samara State Medical University of RMPH; e-mail: andreyy.verbovoyy @ yandex.ru


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