APPLICATION OF ANTICONVULSANTS FROM THE POSITION OF CONCENTRATION MONITORING: CURRENT DATA


Yu.B. Belousov (1), M.V. Leonova (1), L.L. Shteinberg (1), I.F. Tischenkova (1), A.V. Sokolov (2)

(1) SBEI HPE RNSMU n.a. N.I. Pirogov of RMPH, Moscow; (2) SBEI HPE First MSMU n.a. I.M. Sechenov of RMPH, Moscow
The article presents the results of retrospective study on the evaluation of therapeutic drug monitoring (TDM) of anticonvulsants in a real clinical practice. The results of TDM of 614 patients were selected; 295 patients have received the valproic acid, and 319 patients have received carbamazepine. The analysis of TDM of valproate in routine clinical practice has demonstrated the importance of this method for optimization of pharmacotherapy of adult patients with epilepsy. The average therapeutic dose range in actual practice, providing therapeutic levels of valproic acid concentrations, which did not differ for different drugs and dosage forms, was identified. The results TDM of carbamazepine showed that carbamazepine dosage ranges, providing therapeutic, sub- and extratherapeutic concentrations, are extremely broad and practically coincide, despite the higher frequency of achieving the therapeutic concentrations compared with valproate. Therefore, the number of cases of non-achievement of therapeutic concentrations were 2.5 times less, and the number of overdoses - more than 10 times compared with the use of valproate.

About the Autors


Yu.B. Belousov – MD, Prof., Corr. Member of RAMS, Head of the Department of Clinical Pharmacology SBEI HPE RNSMU n.a. N.I. Pirogov of RMPH
M.V. Leonova - MD, Prof., Corr. Member of RANS, Prof. at the Department of Clinical Pharmacology SBEI HPE RNSMU n.a. N.I. Pirogov of RMPH; e-mail: anti23@mail.ru
L.L. Shteinberg – Teaching Assistant at the Department of Clinical Pharmacology SBEI HPE RNSMU n.a. N.I. Pirogov of RMPH
I.F. Tischenkova – PhD in Chemical Sciences, Head of university laboratory at the Department of Clinical Pharmacology SBEI HPE RNSMU n.a. N.I. Pirogov of RMPH
A.V. Sokolov – Doctor of Biological Sciences, Prof. at the Department of Clinical Pharmacology and Propaedeutics of Internal Diseases SBEI HPE First MSMU n.a. I.M. Sechenov of RMPH


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