CHANGES IN STATE OF VASCULATURE IN YOUNG WOMEN WITH ESTROGEN DEFICIENCY, DYSLIPIDEMIA AND ARTERIAL HYPERTENSION AGAINST THE BACKGROUND OF USE OF MERTENIL


M.M. Khabibulina

Department of outpatient therapy, ultrasound and functional diagnostics SBEI HPE "Ural State Medical University" of RMPH, Yekaterinburg; MBI "Yekaterinburg Consultative Diagnostic Center", Yekaterinburg
The article presents the results of duplex scanning of the common carotid arteries (CCA) and assessment of structural and functional state of the vasculature in 47 women with arterial hypertension (AH), dyslipidemia and estrogen deficiency in late fertile period (LFP). Using detailed duplex scanning of CCA, it was found that patients with arterial hypertension and dyslipidemia in the LFP with reduced estradiol levels had an expansion of the CCA lumen, reduced blood flow in the carotid arteries with direct course without hemodynamically relevant stenosis, indicating structural and functional changes in the vascular wall in the form of arteriosclerosis. In patients with arterial hypertension and dyslipidemia in the TFG and poor hormonal profile, during the test of postocclusive reactive hyperemia before treatment, on the background of significant reduction of vasomotor endothelial function, in almost every second case (46.7%) inertial type of vasomotor response is revealed, indicating the contribution of dyslipidemia in the progression of arterial hypertension in dyshormonosis, primarily due to an increase of arterial stiffness and development of endothelial dysfunction. Combination therapy with Mertenil (rosuvastatin) and Ekvator (lisinopril, amlodipine) has significantly better effect on the structural and functional changes in the CCA vascular wall, endothelial dysfunction, and reduces arterial stiffness compared to the therapy with Ekvator (P <0.05).

About the Autors


M.M. Khabibulina - Assistant Professor at the Department of outpatient therapy, ultrasound and functional diagnostics SBEI HPE "Ural State Medical University" of RMPH; e-mail: mmk@edc.nexcom.ru


Similar Articles


Бионика Медиа