ISSN 2073–4034
eISSN 2414–9128

Саркопения у пациентов с воспалительными заболеваниями кишечника (обзор литературы)

К.Ш. Фазлыахметова, Л.Д. Садретдинова, Х.Х. Ганцева, А.С. Сарсенбаева, А.В. Тюрин

1) ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России, г. Уфа, Республика Башкортостан; 2) ФГБОУ ВО «Южно-Уральский государственный медицинский университет» Минздрава России, г. Челябинск, Российская Федерация
Аннотация. В обзоре обобщены современные сведения о саркопении у пациентов с воспалительными заболеваниями кишечника (ВЗК). Рассмотрены данные о частоте встречаемости саркопении, ее клиническом значении, диагностических подходах и предполагаемых механизмах формирования на фоне хронического воспаления, мальабсорбции и нутритивной недостаточности. Представлен практический алгоритм диагностики и изложены актуальные стратегии лечения, основанные на коррекции питания, физической реабилитации и контроле воспалительного процесса. Цель работы – обобщить и систематизировать современные данные о распространенности саркопении у пациентов с ВЗК, раскрыть ключевые механизмы ее патогенеза и диагностические маркеры, а также представить практико-ориентированный алгоритм выявления этого состояния на амбулаторном этапе и подходы к лечению с акцентом на раннюю диагностику и клиническую значимость для оценки активности ВЗК.

Ключевые слова

саркопения
воспалительные заболевания кишечника
биомаркеры саркопении
амбулаторное наблюдение

Список литературы

  1. Mak WY, Zhao M, Ng SC, Burisch J. The epidemiology of inflammatory bowel disease: East meets west. J Gastroenterol Hepatol. 2020;35(3):380–89.

    PMID: 31596960. https://doi.org/10.1111/jgh.14872

  2. Jabłonska B, Mrowiec S. Nutritional status and its detection in patients with inflammatory bowel diseases. Nutrients. 2023;15(8):1991.

    PMID: 37111210. PMCID: PMC10143611. https://doi.org/10.3390/nu15081991

  3. Cankurtaran RE, Gunes YC, Dirican E, Algın O, Cankurtaran D, Tayfur Yurekli O. Sarcopenia and myosteatosis assessed by magnetic resonance enterography may predict negative outcomes in patients with Crohn’s disease. Turk J Gastroenterol. 2023;34(8):839–49.

    PMID: 37404120. PMCID: PMC10543407. https://doi.org/10.5152/tjg.2023.22644

  4. Faye AS, Khan T, Cautha S, Kochar B. Sarcopenia in inflammatory bowel diseases: Reviewing past work to pave the path for the future. Curr Treat Options Gastroenterol. 2022;20(3):250–60.

    PMID: 36388172. PMCID: PMC9648863. https://doi.org/10.1007/s11938-022-00389-8

  5. Bamba S, Sasaki M, Takaoka A, Takahashi K, Imaeda H, Nishida A, et al. Sarcopenia is a predictive factor for intestinal resection in admitted patients with Crohn’s disease. PLoS One. 2017;12(6):e0180036.

    PMID: 28644887. PMCID: PMC5482469. https://doi.org/10.1371/journal.pone.0180036

  6. Садретдинова Л.Д., Ганцева Х.Х., Ахиярова К.Э., Хафизов М.М., Тюрин А.В. Саркопения, ассоциированная с заболеваниями печени и желчевыводящих путей. Экспериментальная и клиническая гастроэнтерология. 2024;(10):179–185. [Sadretdinova LD, Gantseva HH, Akhiyarova KE, Khafizov MM, Tyurin AV. Sarcopenia associated with liver diseases and biliary tract. Eksperimental’naya i klinicheskaya gastroenterologiya = Experimental and Clinical Gastroenterology. 2024;(10):179–185 (In Russ.)].

    EDN: HLWLAE. https://doi.org/10.31146/1682-8658-ecg-230-10-179-185

  7. Massironi S, Vigano C, Palermo A, Pirola L, Mulinacci G, Allocca M, et al. Inflammation and malnutrition in inflammatory bowel disease. Lancet Gastroenterol Hepatol. 2023;8(6):579–90.

    PMID: 36933563. https://doi.org/10.1016/S2468-1253(23)00011-0

  8. Ryan E, McNicholas D, Creavin B, Kelly ME, Walsh T, Beddy D. Sarcopenia and inflammatory bowel disease: A systematic review. Inflamm Bowel Dis. 2019;25(1):67–73.

    PMID: 29889230. https://doi.org/10.1093/ibd/izy212

  9. Unal NG, Oruc N, Tomey O, Omer Ozutemiz A. Malnutrition and sarcopenia are prevalent among inflammatory bowel disease patients with clinical remission. Eur J Gastroenterol Hepatol. 2021;33(11):1367–75.

    PMID: 33470696. https://doi.org/10.1097/MEG.0000000000002044

  10. Gold SL, Raman M, Sands BE, Ungaro R, Sabino J. Review article: Putting some muscle into sarcopenia – the pathogenesis, assessment and clinical impact of muscle loss in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2023;57(11):1216–30.

    PMID: 37051722. https://doi.org/10.1111/apt.17498

  11. Pizzoferrato M, de Sire R, Ingravalle F, Mentella MC, Petito V, Martone AM, et al. Characterization of sarcopenia in an IBD population attending an Italian gastroenterology tertiary center. Nutrients. 2019;11(10):2281.

    PMID: 31554166. PMCID: PMC6835412. https://doi.org/10.3390/nu11102281

  12. Dermine S, Bazin T, Hassan FA, Bettolo J, Billiauws L, Bourdillel J, et al. Prevalence and impact of sarcopenia in patients with inflammatory bowel diseases: A prospective cohort study. Clin Res Hepatol Gastroenterol. 2025;49(4):102555.

    PMID: 40021084. https://doi.org/10.1016/j.clinre.2025.102555

  13. Bezzio C, Brinch D, Ribaldone DG, Cappello M, Ruzzon N, Vernero M, et al. Prevalence, risk factors and association with clinical outcomes of malnutrition and sarcopenia in inflammatory bowel disease: A prospective study. Nutrients. 2024;16(23):3983.

    PMID: 39683376. PMCID: PMC11643262. https://doi.org/10.3390/nu16233983

  14. Neelam PB, Sharma A, Sharma V. Sarcopenia and frailty in inflammatory bowel disease: emerging concepts and evidence. JGH Open. 2024;8(1):e13033.

    PMID: 38283070. PMCID: PMC10821747. https://doi.org/10.1002/jgh3.13033

  15. Kreienbuehl AS, Rogler G, Emanuel B, Biedermann L, Meier C, Juillerat P, et al. Bone health in patients with inflammatory bowel disease. Swiss Med Wkly. 2024;154:3407.

    PMID: 38875461. https://doi.org/10.57187/s.3407

  16. He C, Huang G, Bi J, Fu W, Liu CJ. cPLA2 in musculoskeletal and autoimmune diseases: Molecular mechanisms and therapeutic insights. Cytokine Growth Factor Rev. 2026;88:18–31.

    PMID: 41512597. https://doi.org/10.1016/j.cytogfr.2026.01.002

  17. Marzban Abbas Abadi M, Emadian ST, Zamani M, Khalilizad M. Prevalence of osteoporosis in patients with inflammatory bowel disease: A systematic review and meta-analysis. J Health Popul Nutr. 2025;44(1):178.

    PMID: 40442831. PMCID: PMC12123853. https://doi.org/10.1186/s41043-025-00946-8

  18. Calvez V, Becherucci G, Covello C, Piccirilli G, Mignini I, Esposto G, et al. Navigating the intersection: Sarcopenia and sarcopenic obesity in inflammatory bowel disease. Biomedicines. 2024;12(6):1218.

    PMID: 38927425. PMCID: PMC11200968. https://doi.org/10.3390/biomedicines12061218

  19. Maresca R, Mignini I, Varca S, Calvez V, Termite F, Esposto G, et al. Inflammatory bowel diseases and non-alcoholic fatty liver disease: Piecing a complex puzzle together. Int J Mol Sci. 2024;25(6):3278.

    PMID: 38542249. PMCID: PMC10970310. https://doi.org/10.3390/ijms25063278

  20. Sleutjes JAM, van der Woude CJ, Verploegh PJP, Aribas E, Kavousi M, Roeters van Lennep JE, de Vries AC. Cardiovascular risk profiles in patients with inflammatory bowel disease. Eur J Prev Cardiol. 2023;30(15):1615–22.

    PMID: 37075221. https://doi.org/10.1093/eurjpc/zwad124

  21. Noble O, Jeon D, Lewis M, Fan C, Nasir K, Abraham BP. From gut inflammation to cardiovascular conflagration: Mapping IBD’s cardiometabolic risks. Curr Atheroscler Rep. 2025;27(1):89.

    PMID: 40928712. https://doi.org/10.1007/s11883-025-01329-4

  22. Sanchez Cruz C, Rojas Huerta A, Lima Barrientos J, Rodriguez C, Devani A, Boosahda V, et al. Inflammatory bowel disease and cardiovascular disease: An integrative review with a focus on the gut microbiome. Cureus. 2024;16(7):e65136.

    PMID: 39170992. PMCID: PMC11338650. https://doi.org/10.7759/cureus.65136

  23. Barone M, Baccaro P, Molfino A. An overview of sarcopenia: Focusing on nutritional treatment approaches. Nutrients. 2025;17(7):1237.

    PMID: 40218995. PMCID: PMC11990658. https://doi.org/10.3390/nu17071237

  24. de Sire A, de Sire R, Petito V, Masi L, Cisari C, Gasbarrini A, et al. Gut-joint axis: The role of physical exercise on gut microbiota modulation in older people with osteoarthritis. Nutrients. 2020;12(2):574.

    PMID: 32098380. PMCID: PMC7071456. https://doi.org/10.3390/nu12020574

  25. Halfvarson J, Brislawn CJ, Lamendella R, Vazquez-Baeza Y, Walters WA, Bramer LM, et al. Dynamics of the human gut microbiome in inflammatory bowel disease. Nat Microbiol. 2017;2:17004.

    PMID: 28191884. PMCID: PMC5319707. https://doi.org/10.1038/nmicrobiol.2017.4

  26. Ni J, Wu GD, Albenberg L, Tomov VT. Gut microbiota and IBD: causation or correlation? Nat Rev Gastroenterol Hepatol. 2017;14(10):573–84.

    PMID: 28743984. PMCID: PMC5880536. https://doi.org/10.1038/nrgastro.2017.88

  27. Shah A, Morrison M, Burger D, Martin N, Rich J, Jones M, et al. Systematic review with meta-analysis: The prevalence of small intestinal bacterial overgrowth in inflammatory bowel disease. Aliment Pharmacol Ther. 2019;49(6):624–35.

    PMID: 30735254. https://doi.org/10.1111/apt.15133

  28. Singh A, Wall C, Levine A, Midha V, Mahajan R, Sood A. Nutritional screening and assessment in inflammatory bowel disease. Indian J Gastroenterol. 2022;41(1):5–22.

    PMID: 35031977. https://doi.org/10.1007/s12664-021-01223-2

  29. Bian AL, Hu HY, Rong YD, Wang J, Wang JX, Zhou XZ. A study on relationship between elderly sarcopenia and inflammatory factors IL-6 and TNF-α. Eur J Med Res. 2017;22(1):25.

    PMID: 28701179. PMCID: PMC5508730. https://doi.org/10.1186/s40001-017-0266-9

  30. Валеева Ф.В., Родыгина Ж.А., Йылмаз Т.С. Роль генов и миокинов в прогнозировании риска развития саркопении. Consilium Medicum. 2024;26(4):219–24. Valeeva FV, Rodygina ZA, Yilmaz TS. The role of genes and myokines of developing sarcopenia: A review. Consilium Medicum. 2024;26(4):219–24 (In Russ.)].

    EDN: UHKJUI. https://doi.org/10.26442/20751753.2024.4.202735

  31. Guo M, Yao J, Li J, Zhang J, Wang D, Zuo H, et al. Irisin ameliorates age-associated sarcopenia and metabolic dysfunction. J Cachexia Sarcopenia Muscle. 2023;14(1):391–405.

    PMID: 36510115. PMCID: PMC9891925. https://doi.org/10.1002/jcsm.13141

  32. Бикбавова Г.Р., Ливзан М.А., Тихонравова Д.В., Лисютенко Н.С., Романюк А.Е. Саркопения и воспалительные заболевания кишечника: механизм развития и практическое значение. РМЖ. 2023;(5):39–42. [Bikbavova GR, Livzan MA, Tikhonravova DV, Lisyutenko NS, Romanyuk AE. Sarcopenia and inflammatory bowel diseases: Pathogenetic mechanism and practical significance. Russkiy meditsinskiy zhurnal = Russian Medical Journal. 2023;(5):39–42 (In Russ.)]. EDN: DTKQMJ.
  33. Abdelrahman Z, Wang X, Wang D, Zhang T, Zhang Y, Wang X, Chen Z. Identification of novel pathways and immune profiles related to sarcopenia. Front Med (Lausanne). 2023;10:928285.

    PMID: 37138756. PMCID: PMC10149827. https://doi.org/10.3389/fmed.2023.928285

  34. Nishikawa H, Nakamura S, Miyazaki T, Kakimoto K, Fukunishi S, Asai A, et al. Inflammatory bowel disease and sarcopenia: Its mechanism and clinical importance. J Clin Med. 2021;10(18):4214.

    PMID: 34575326. PMCID: PMC8470813. https://doi.org/10.3390/jcm10184214

  35. Mafi F, Biglari S, Ghardashi Afousi A, Gaeini AA. Improvement in skeletal muscle strength and plasma levels of follistatin and myostatin induced by an 8-week resistance training and epicatechin supplementation in sarcopenic older adults. J Aging Phys Act. 2019;27(3):384–91.

    PMID: 30299198. https://doi.org/10.1123/japa.2017-0389

  36. Choi K, Jang HY, Ahn JM, Hwang SH, Chung JW, Choi YS, et al. The association of the serum levels of myostatin, follistatin, and interleukin-6 with sarcopenia, and their impacts on survival in patients with hepatocellular carcinoma. Clin Mol Hepatol. 2020;26(4):492–505.

    PMID: 32646201. PMCID: PMC7641544. https://doi.org/10.3350/cmh.2020.0005

  37. Harada M, Morikawa M, Ozawa T, Kobayashi M, Tamura Y, Takahashi K, et al. Palbociclib enhances activin-SMAD-induced cytostasis in estrogen receptor-positive breast cancer. Cancer Sci. 2019;110(1):209–20.

    PMID: 30343527. PMCID: PMC6317929. https://doi.org/10.1111/cas.13841

  38. Godala M, Gaszynska E, Walczak K, Małecka-Wojciesko E. Myostatin and activin A as biomarkers of sarcopenia in inflammatory bowel disease patients. Nutrients. 2024;16(6):810.

    PMID: 38542721. PMCID: PMC10974648. https://doi.org/10.3390/nu16060810

  39. Cakar S, Eren G, Erdur CB, Onder M, Pelek S, Demirtas D, et al. Are vitamin D levels related to sarcopenia in children with inflammatory bowel disease? J Clin Med. 2025;14(5):1548.

    PMID: 40095479. PMCID: PMC11900381. https://doi.org/10.3390/jcm14051548

  40. Ooi PH, Thompson-Hodgetts S, Pritchard-Wiart L, Gilmour SM, Mager DR. Pediatric sarcopenia: A paradigm in the overall definition of malnutrition in children? JPEN J Parenter Enteral Nutr. 2020;44(3):407–18.

    PMID: 31328301. https://doi.org/10.1002/jpen.1681

  41. Cakar S, Eren G. Diagnosis of sarcopenia with magnetic resonance imaging of newly diagnosed pediatric inflammatory bowel disease. Ann Clin Anal Med. 2023;14(Suppl 3):301–5.

    https://doi.org/10.4328/ACAM.21913

  42. Caraceni P, Domenicali M, Tovoli A, Napoli L, Ricci CS, Tufoni M, Bernardi M. Clinical indications for the albumin use: Still a controversial issue. Eur J Intern Med. 2013;24(8):721–28.

    PMID: 23790570. https://doi.org/10.1016/j.ejim.2013.05.015

  43. Zhang Q, Pereira SL, Luo M, Matheson EM. Evaluation of blood biomarkers associated with the risk of malnutrition in older adults: A systematic review and meta-analysis. Nutrients. 2017;9(8):829.

    PMID: 28771192. PMCID: PMC5579622. https://doi.org/10.3390/nu9080829

  44. Ingenbleek Y. Plasma transthyretin is a nutritional biomarker in human morbidities. Front Med. 2022;16(4):540–50.

    PMID: 35943703. PMCID: PMC9361973. https://doi.org/10.1007/s11684-022-0940-3

  45. Loh KW, Vriens MR, Gerritsen A, Borel Rinkes IH, van Hillegersberg R, Schippers C, et al. Unintentional weight loss is the most important indicator of malnutrition among surgical cancer patients. Neth J Med. 2012;70(8):365–69. PMID: 23065984.
  46. Wiech P, Dąbrowski M, Bazalinski D, Salacinska I, Korczowski B, Binkowska-Bury M. Bioelectrical impedance phase angle as an indicator of malnutrition in hospitalized children with diagnosed inflammatory bowel diseases: A case-control study. Nutrients. 2018;10(4):499.

    PMID: 29673210. PMCID: PMC5946284. https://doi.org/10.3390/nu10040499

  47. Papadimitriou K, Detopoulou P, Soufleris K, Voulgaridou G, Tsoumana D, Ntopromireskou P, et al. Nutritional risk and sarcopenia features in patients with Crohn’s disease: Relation to body composition, physical performance, nutritional questionnaires and biomarkers. Nutrients. 2023;15(16):3615.

    PMID: 37630805. PMCID: PMC10458234. https://doi.org/10.3390/nu15163615

  48. Martin P, Botsen D, Brugel M, Bertin E, Carlier C, Mahmoudi R, et al. Association of low handgrip strength with chemotherapy toxicity in digestive cancer patients: A comprehensive observational cohort study (FIGHTDIGOTOX). Nutrients. 2022;14(21):4448.

    PMID: 36364711. PMCID: PMC9654937. https://doi.org/10.3390/nu14214448

  49. Жданова А.С., Белая Ж.Е., Омельченко К.А., Айрапетов Г.А. Возможности диагностики саркопении: клинические, лабораторные, инструментальные. Остеопороз и остеопатии. 2025;28(3):12–23. [Zhdanova AS, Belaya ZE, Omelchenko KA, Airapetov GA. Clinical, laboratory and instrumental aspects of sarcopenia diagnostics. Osteoporoz i osteopatii = Osteoporosis and Bone Diseases. 2025;28(3):12–23 (In Russ.)].

    EDN: GNREFO. https://doi.org/10.14341/osteo13206

  50. Seron-Arbeloa C, Labarta-Monzon L, Puzo-Foncillas J, Mallor-Bonet T, Lafita-Lopez A, Bueno-Vidales N, Montoro-Huguet M. Malnutrition screening and assessment. Nutrients. 2022;14(12):2392.

    PMID: 35745121. PMCID: PMC9228435. https://doi.org/10.3390/nu14122392

  51. Kruizenga HM, Seidell JC, de Vet HC, Wierdsma NJ, van Bokhorst-de van der Schueren MA. Development and validation of a hospital screening tool for malnutrition: The short nutritional assessment questionnaire (SNAQ). Clin Nutr. 2005;24(1):75–82.

    PMID: 15681104. https://doi.org/10.1016/j.clnu.2004.07.015

  52. Rubenstein LZ, Harker JO, Salvà A, Guigoz Y, Vellas B. Screening for undernutrition in geriatric practice: developing the short-form mini-nutritional assessment (MNA-SF). J Gerontol A Biol Sci Med Sci. 2001;56(6):M366–M372.

    PMID: 11382797. https://doi.org/10.1093/gerona/56.6.m366

  53. Boros KK, Veres G, Pinter HK, Richter E, Cseh A, Dezsofi A, et al. Novel approach to assess sarcopenia in children with inflammatory bowel disease. Front Pediatr. 2024;12:1204639.

    PMID: 39629099. PMCID: PMC11611584. https://doi.org/10.3389/fped.2024.1204639

  54. Hu Q, Long Q, Wang W, Ma M. Bioelectrical impedance analysis for measuring body composition and predicting low muscle mass in apparently healthy pediatric outpatients: A retrospective observational study. BMC Pediatr. 2025;25(1):303.

    PMID: 40241085. PMCID: PMC12004640. https://doi.org/10.1186/s12887-025-05579-8

  55. Celentano V, Kamil-Mustafa L, Beable R, Ball C, Flashman KG, Jennings Z, et al. Preoperative assessment of skeletal muscle mass during magnetic resonance enterography in patients with Crohn’s disease. Updates Surg. 2021;73(4):1419–27.

    PMID: 32410158. PMCID: PMC8397655. https://doi.org/10.1007/s13304-020-00790-x

  56. Perkisas S, Bastijns S, Baudry S, Bauer J, Beaudart C, Beckwee D, et al. Application of ultrasound for muscle assessment in sarcopenia: 2020 SARCUS update. Eur Geriatr Med. 2021;12(1):45–59.

    PMID: 33387359. https://doi.org/10.1007/s41999-020-00433-9

  57. Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyere O, Cederholm T, et al.; Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: Revised European consensus on definition and diagnosis. Age Ageing. 2019;48(1):16–31.

    PMID: 30312372. PMCID: PMC6322506. https://doi.org/10.1093/ageing/afy169. Erratum in: Age Ageing. 2019;48(4):601.

    https://doi.org/10.1093/ageing/afz046

  58. Haskey N, Pena-Sanchez JN, Jones JL, Fowler SA. Development of a screening tool to detect nutrition risk in patients with inflammatory bowel disease. Asia Pac J Clin Nutr. 2018;27(4):756–62.

    PMID: 30045418. https://doi.org/10.6133/apjcn.112017.01

  59. Gold SL, Bhanji RA, Epp S, Tandon P. Putting some muscle into sarcopenia: The pathogenesis, assessment and clinical impact of muscle loss in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2023;57(8):807–23.

    PMID: 36645152. PMCID: PMC11497233. https://doi.org/10.1111/apt.17392

  60. RadiologyInfo. Bone density scan (DEXA or DXA). Last reviewed on March 11, 2024. URL: https://www.radiologyinfo.org/en/info/dexa (date of access – 15.08.2026).
  61. Volkert D, Beck AM, Cederholm T, Cruz-Jentoft A, Hooper L, Kiesswetter E, et al. ESPEN practical guideline: Clinical nutrition and hydration in geriatrics. Clin Nutr. 2022;41(4):958–89.

    PMID: 35306388. https://doi.org/10.1016/j.clnu.2022.01.02

  62. Deutz NE, Bauer JM, Barazzoni R, Biolo G, Boirie Y, Bosy-Westphal A, et al. Protein intake and exercise for optimal muscle function with aging: Recommendations from the ESPEN Expert Group. Clin Nutr. 2014;33(6):929–36.

    PMID: 24814383. PMCID: PMC4208946. https://doi.org/10.1016/j.clnu.2014.04.007

  63. Liu S, Zhang L, Li S. Advances in nutritional supplementation for sarcopenia management. Front Nutr. 2023;10:1189522.

    PMID: 37492597. PMCID: PMC10365293. https://doi.org/10.3389/fnut.2023.1189522

  64. Zhang F, Li W. Vitamin D and sarcopenia in the senior people: A review of mechanisms and comprehensive prevention and treatment strategies. Ther Clin Risk Manag. 2024;20:577–95.

    PMID: 39253031. PMCID: PMC1138265. https://doi.org/10.2147/TCRM.S471191

Об авторах / Для корреспонденции

Камилла Шамилевна Фазлыахметова, студентка 4 курса лечебного факультета ФГБОУ ВО БГМУ Минздрава России, Уфа, Республика Башкортостан.
E-mail: Kamilla14.03@mail.ru
Лидия Данисовна Садретдинова, к. м. н., доцент кафедры внутренних болезней ФГБОУ ВО БГМУ Минздрава России, Уфа, Республика Башкортостан.
E-mail: shuraleyka1@mail.ru
ORCID: https://orcid.org/0000-0001-9421-9545
Халида Ханафиевна Ганцева, д. м. н., профессор кафедры внутренних болезней ФГБОУ ВО БГМУ Минздрава России, Уфа, Республика Башкортостан.
E-mail: halide.ganceva@mail.ru
ORCID: https://orcid.org/0000-0002-7217-7222
Айман Силкановна Сарсенбаева, д. м. н., профессор кафедры терапии ИДПО ФГБОУ ВО ЮУГМУ Минздрава России, Челябинск, Российская Федерация.
E-mail: aiman-ss@yandex.ru
ORCID: https://orcid.org/0000-0001-5922-2271
Антон Викторович Тюрин, д. м. н., доцент, заведующий кафедрой внутренних болезней ФГБОУ ВО БГМУ Минздрава России, Уфа, Республика Башкортостан.
E-mail: anton.bgmu@gmail.com
ORCID: https://orcid.org/0000-0002-0841-3024

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