Клиническая фармакология ингибиторов натрий-глюкозного котранспортера-2


DOI: https://dx.doi.org/10.18565/pharmateca.2024.4.216-226

Леонова М.В.

Межрегиональной общественной организации Ассоциации клинических фармакологов (Московское отделение), Москва, Россия
Представлен обзор по клинической фармакологии нового класса пероральных сахароснижающих препаратов – ингибиторов натрий-глюкозного котранспортера-2 (иНГЛТ-2, или глифлозинов). Описан основной механизм действия иНГЛТ-2, а также других метаболических, сердечно-сосудистых, почечных эффектов, которые относятся к плейотропным класс-эффектам. Представлены данные по фармакодинамике, фармакокинетике препаратов (дапаглифлозин, канкглифлозин, эмпаглифлозин, эртуглифлозин, ипраглифлозин, лусеоглифлозин, сотаглифлозин); побочные эффекты и лекарственные взаимодействия. Данные по клинической фармакологии класса иНГЛТ-2 будут способствовать лучшему пониманию основного механизма действия и плейотропных эффектов, обеспечивающих кардиопротекторное и ренопротекторное действия.

Литература


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Об авторах / Для корреспонденции


Автор для связи: Марина Васильевна Леонова, д.м.н., профессор, член-корр. РАЕН, Член Межрегиональной общественной организации Ассоциации клинических фармакологов (Московское отделение), Москва, Россия; anti23@mail.ru; ORCID: https://orcid.org/0000-0001-8228-1114; eLibrary SPIN: 3281-7884


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