Новые возможности профилактики тошноты и рвоты при проведении химиотерапии


Абрамов М.Е., Лодыгина К.С.

ФГБУ “Онкологический научный центр им. Н.Н. Блохина” РАМН, Москва
Первым представителем нового класса антиэметиков- антагонистов нейрокининовых рецепторов - 1 (NK1), является селективный блокатор рецепторов NK1- апрепитант (Эменд®) и его внутривенная форма - Эменд® В/В.Этот препарат более удобен в использовании, так как вводится однократно внутривенно перед проведением химиотерапии, имеет равную эффективность с апрепитантом, и, в отличие от него, не требует дополнительного приема или введения в последующие дни.Фосапрепитант вошел во все клинические рекомендациидля профилактики тошноты и рвотыв комбинации сантагонистом рецептора 5-НТ3 и дексаметазоном при проведении высоко – и в некоторых случаях умеренноэметогенной химиотерапии. Препарат обладает минимальным спектром побочных действий.

Литература


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Об авторах / Для корреспонденции


М.Е. Абрамов – к.м.н., с.н.с., ФГБУ РОНЦ им. Н.Н. Блохина, Москва; e-mail: mikhailabramov@newmail.ru
К.С. Лодыгина – ординатор кафедры онкологии и лучевой терапии ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздрава России, Москва


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