Acute Management Of Pain Syndromes In Gynecology


I.A. Apolikhina, T.A. Teterina

Lower abdominal pain is the most common complaint in gynecological practice. This symptom is non-specific, because it occurs in many diseases. The main objective in the treatment of patients with pain syndrome is decrease of pain intensity. The main groups of drugs used for pain relief are divided on analgesics (narcotic and non-narcotic) and anesthetic agents (local and general). Currently, a broad arsenal of non-steroidal anti-inflammatory drugs (NSAIDs) is available. Special attention is given to the drugs with potent pharmacological profile, favorable combination of clinical efficacy and safety, which have various forms of release. Ketoprofen (Ketonal) refers to a group of non-selective NSAIDs, which optimally balances the inhibition of cyclooxygenase-1 (COX-1) and COX-2; and this feature provides a powerful analgesic effect. Moreover, small molecular size and high lipophilicity, unlike most other NSAIDs, allows to penetrate the central nervous system (CNS), and additionally provides a central analgesic effect. NSAIDs are used in gynecological practice in the treatment of dysmenorrhea, pelvic inflammatory diseases (PID), pelvic ganglioneuritis, as well as for the premedication before various minimally invasive interventions.

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