Problem of replacement hormonal therapy from the point of view of evidence-based medicine
Till now there is uncertainty concerning of benefits and risk of the hormone replacement therapy (HRT) in menopause regarding its effects on the cardiovascular system, breast, thromboembolic complications, cognitive disturbances and Alzheimer disease. If the women’s quality of life is not decreased and menopause can be considered physiological, the risk of HRT is not approving its using. But in the same time, if the menopause symptoms exist, HRT is the only and effective way of its reduction, improving of quality of life and sexuality. There are no other therapies which can be compared with HRT. The article includes the recommendations of the Executive committee of the International associations of menopause of HRT using during menopause, developed on the basis of results of metaanalysis of many trials.

Keywords: progestagens, estrogens, hormone replacement therapy, menopause