Depression in epilepsy: pathogenetic mechanisms and approaches to treatment
Various forms of the depression are often accompanied by epilepsy that leads to significantly deterioration of patient’s quality of life. Along with the cognitive processes distortion, depressive change of mood is accompanied by motor inhibition, decrease in motivation to work, and somatovegetative dysfunction. We discuss the epidemiology, clinical manifestation, diagnosis and causes of depressive disorders in epilepsy. The common characteristics of pathogenic mechanisms of epilepsy and depression are emphasized. We consider the treatment peculiarities of depressive disorders in epilepsy. Data for the use of selective serotonin reuptake inhibitors, including citalopram, to this effect are presented.