Physical properties of surfactant as a basis for its effectiveness in the experiment


DOI: https://dx.doi.org/10.18565/pharmateca.2025.6.78-87

Mostovoi A.V., Karpova A.L., Burenkov R.A, Ermoolinsky P.B., Lugovtsov A.E., Vorobyeva S.V., Sinitsa D.R., Igina I.M., Nekhoroshkin S.A., Volodin N.N.

1) Vorokhobov City Clinical Hospital No. 67 of the Moscow Healthcare Department, Russia; 2) Russian Medical Academy of Continuous Professional Education, Moscow, Russia; 3) Yaroslavl State Medical University, Yaroslavl, Russia; 4) Kaluga Regional Children’s Clinical Hospital, Kaluga, Russia; 5) Lomonosov Moscow State University, Moscow, Russia; 6) Dmitry Rogachev National Medical Research Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russia
The article presents data on our experimental studies devoted to the effects of different concentrations of poractant alpha (80 mg/ml and 40 mg/ml) on its distribution in a biological lung model. Neutral aqueous ink served as a marker, for which the surfactant was a conductor solution. The homogeneity of the surfactant distribution could be judged by visual observation, as well as pathological examination of macro- and micropreparations. Preliminary, the viscosity of surfactants, the fluidity of poractant alpha (PA) were analyzed in laboratory conditions, and capillary phenomena were studied using PA with different concentrations. In laboratory conditions, the PA solution with a phospholipid concentration of 40 mg/ml demonstrated the lowest viscosity and, as a result, higher fluidity than PA 80 mg/ml. The surfactant with a lower viscosity was more evenly distributed in the biological model of rabbit lungs, which improved their straightening, which required lower mechanical ventilation parameters, and was combined with less severe damage to the alveolar tissue.
Keywords: biological model of the lung, alveolar damage, surfactant distribution, viscosity, pulmonary surfactants, tauractant, beractant, concentration, respiratory distress syndrome, poractant alpha
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About the Autors

Aleksei V. Mostovoi, Cand. Sci. (Med.), Head of the Neonatal Intensive Care Unit, Vorokhobov City Clinical Hospital No. 67 of the Moscow Healthcare Department (Moscow); Associate Professor, Department of Neonatology named after V.V. Gavryushov, Russian Medical Academy of Continuous Professional Education (Moscow); Assistant, Department of Outpatient Therapy, Clinical Laboratory Diagnostics and Medical Biochemistry, Faculty of Postgraduate Education, Yaroslavl State Medical University, Yaroslavl, Russia; valmost@mail.ru, ORCID: https://orcid.org/0000-0002-7040-9683 (corresponding author)
Anna L. Karpova, Cand. Sci. (Med.), Head of Neonatal Department, Vorokhobov City Clinical Hospital No. 67 of the Moscow Healthcare Department (Moscow); Associate Professor, Department of Neonatology named after V.V. Gavryushov, Russian Medical Academy of Continuous Professional Education (Moscow); Assistant, Department of Outpatient Therapy, Clinical Laboratory Diagnostics and Medical Biochemistry, Faculty of Postgraduate Education, Yaroslavl State Medical University, Yaroslavl, Russia; anna1409@mail.ru, ORCID: https://orcid.org/0000-0002-1024-0230
Roman A. Burenkov, Head of Department, Pathologist, Kaluga Regional Clinical Children’s Hospital, Kaluga, Russia; burenkov.kodb@gmail.com, ORCID: https://orcid.org/0000-0002-4102-0644
Petr B. Ermolinsky, Researcher, Laboratory of Biomedical Photonics, Faculty of Physics, Lomonosov Moscow State University, Moscow, Russia; ORCID: https://orcid.org/0000-0002-4688-2307
Andrey E. Lugovtsov, Senior Researcher, Laboratory of Biomedical Photonics, Faculty of Physics, Lomonosov Moscow State University, Moscow, Russia; anlug1@gmail.com, ORCID: https://orcid.org/0000-0001-5222-8267
Svetlana V. Vorobyeva, Anesthesiologist-Intensivist, Vorokhobov City Clinical Hospital No. 67 of the Moscow Healthcare Department, Moscow, Russia; Svetilnikvv@mail.ru, ORCID: https://orcid.org/0009-0006-8472-1201
Daria R. Sinitsa, Anesthesiologist-Intensivist, Vorokhobov City Clinical Hospital No. 67 of the Moscow Healthcare Department, Moscow, Russia; sinitsadaria@yandex.ru, ORCID: https://orcid.org/0009-0004-7083-4171
Irina M. Igina, Anesthesiologist-Intensivist, Vorokhobov City Clinical Hospital No. 67 of the Moscow Healthcare Department, Moscow, Russia;
ign.irn@mail.ru, ORCID: https://orcid.org/0000-0002-7733-4258
Sergei A. Nekhoroshkin, Physician, Clinical Resident, Department of Neonatology named after V.V. Gavryushov, Russian Medical Academy of Continuous Professional Education, Moscow, Russia; nekhoroshkin2000@gmail.com, ORCID: https://orcid.org/0009-0006-3851-5247
Nikolai N. Volodin, Dr. Sci. (Med.), Professor, Full Member of the Russian Academy of Sciences, President of the Russian Association of Perinatal Medicine Specialists; Head of the Department of Pediatrics, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia; 0209vnn@mail.ru, ORCID: https://orcid.org/0000-0002-2667-8229


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