Clinical significance of morphological ultrastaging in breast and uterine cancer


DOI: https://dx.doi.org/10.18565/pharmateca.2025.3.39-43

Khakimova G.G., Reshetov I.V., Zikiryakhodjaev A.D., Khakimova Sh.G.

1) Tashkent City Branch of the Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology, Tashkent, Republic of Uzbekistan; 2) Tashkent Pediatric Medical Institute, Tashkent, Republic of Uzbekistan; 3) Levshin Institute of Cluster Oncology, Sechenov First Moscow State Medical University, Moscow, Russia; 4) N.V. Sklifosovsky Institute of Clinical Medicine, Moscow, Russia; 5) P.A. Herzen Moscow Research Oncology Institute – Branch of the National Medical Research Center of Radiology, Moscow, Russia; 6) I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia; 7) People’s Friendship University of Russia (RUDN University), Moscow, Russia
The condition of the lymph nodes is an important prognostic factor and criterion for adjuvant therapy in malignant neoplasms (MN), while the detection of micrometastases using ultrastaging methods correlates with a poor prognosis in a number of MN and is part of the standard treatment of patients with such a pathology as skin melanoma. In such nosologies as carcinoma of the corpus uteri, breast and colon, ultrastaging of the lymph nodes remains a subject of discussion. The significance of ultrastaging of the sentinel lymph node in choosing treatment tactics for breast cancer and reducing the risk of locoregional recurrence remains a subject of discussion.
Keywords: micrometastases, ultrastaging, corpus uteri cancer, immunohistochemistry
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About the Autors

Gulnoz G. Khakimova, Associate Professor of the Department of Children Oncology, Palliative Care, Tashkent Pediatric Medical Institute; Oncologist of the Chemotherapy Department, Tashkent City Branch of the Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology, Tashkent, Uzbekistan; hgg_doc@mail.ru, ORCID: https://orcid.org/0000-0002-4970-5429 (corresponding author)
Igor V. Reshetov, Academician of RAS, Dr. Sci. (Med.), Professor, Director of the Levshin Institute of Cluster Oncology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Head of the Department of Oncology, Radiotherapy and Reconstructive Surgeryof the N.V. Sklifosovsky Institute of Clinical Medicine, Moscow, Russia; 2487784@mail.ru, SPIN-код: 3845-6604, ORCID: https://orcid.org/0000-0002-0909-6278
A.D. Zikiryakhodjaev, Dr. Sci. (Med.), Professor, Head of the Department of Reconstructive Plastic Surgery of the Breast and Skin, P.A. Herzen Moscow Research Oncology Institute – Branch of the National Medical Research Center of Radiology; I.M. Sechenov First Moscow State Medical University (Sechenov University); Associate Professor of the Department of Oncology, People’s Friendship University of Russia (RUDN University), Moscow, Russia; ORCID: https://orcid.org/0000-0001-7141-2502
Shakhnoz G. Khakimova, Associate Professor of the Department of Pediatric Oncology, Tashkent Pediatric Medical Institute (Tashkent, Uzbekistan); Dr. Sci. (Med.), Trainee of the Department of Reconstructive Plastic Surgery of the Breast and Skin, P.A. Herzen Moscow Research Oncology Institute – Branch of the National Medical Research Center of Radiology, Moscow, Russia; shahnoz_khakimova@mail.ru, ORCID: https://orcid.org/0000-0002-9491-0413

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