The role of laboratory tests in the diagnosis of dermatitis herpetiformis


DOI: https://dx.doi.org/10.18565/pharmateca.2025.4.129-133

Nemchaninova O.B., Reshetnikova T.B., Pozdnyakova O.N., Chasnyk A.S.

Novosibirsk State Medical University, Novosibirsk, Russia
Dermatitis herpetiformis (DH) is an acquired bullous dermatosis characterized by itchy polymorphic rashes, formation of subepidermal blisters and granular deposition of immunoglobulin class A (IgA) in the dermal papillae. Diagnosis of DH requires a comprehensive assessment of the clinical picture and laboratory data. The article discusses the clinical, cytological, histological and immunopathological signs of this disease, on the basis of which differential diagnostics is carried out
DH with other bullous dermatoses. Two clinical cases demonstrating the role of laboratory diagnostic tests in complex clinical situations are presented.
Keywords: immunogenetic study, immunofluorescence diagnostics, histological examination of biopsy material, bullous pemphigoid, Duhring’s dermatitis, dermatitis herpetiformis, cytological examination
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About the Autors

Olga B. Nemchaninova, Dr. Sci. (Med.), Professor, Head of the Department of Dermatovenereology and Cosmetology, Novosibirsk State Medical University, Novosibirsk, Russia; obnemchaninova@mail.ru, ORCID: https://orcid.org/0000-0002-5961-6980 (corresponding author)
T.B. Reshetnikova, Dr. Sci. (Med.), Professor, Department of Dermatovenereology and Cosmetology, Novosibirsk State Medical University, Novosibirsk, Russia; tatyanaresh@mail.ru, ORCID: https://orcid.org/0000-0002-6156-0875
O.N. Pozdnyakova, Dr. Sci. (Med.), Professor, Department of Dermatovenereology and Cosmetology, Novosibirsk State Medical University, Novosibirsk, Russia; pozdnyakova.o.n@mail.ru, ORCID: https://orcid.org/0000-0003-1389-1001
A.S. Chasnyk, Teaching Assistant, Department of Dermatovenereology and Cosmetology, Novosibirsk State Medical University, Novosibirsk, Russia; annachasnyk@yandex.ru, ORCID: https://orcid.org/0009-0002-3663-1827

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