Diabetic neuropathy: pathophysiological mechanisms and metabolic therapy

DOI: https://dx.doi.org/10.18565/pharmateca.2023.12.52-57

I.A. Kurnikova

RUDN University, Moscow, Russia
The presented scientific and analytical article discusses the modern scientific literature data on structural and physiological changes in nervous tissue in patients with diabetes mellitus. A complex of mechanisms leading to disruption of antioxidant protection, changes in protein structure and activity of enzyme systems, leading to hypoxia, the development of axonal degeneration and demyelenation of nerve fibers, has been analyzed. The multicomponent nature of metabolic disorders has been identified as the main problem that needs to be solved, which dictates the need to find and use means with not just precise, but also complex effects. Analysis of data on the presentation of domestic drugs with complex effects on the Russian pharmaceutical market drew our attention to a drug containing inosine +nicotinamide+riboflavin+succinic acid.. Pharmacokinetics of Cytoflavin allows it to simultaneously influence several pathophysiological mechanisms, providing to predict the complex effect on metabolic processes in nervous tissue. Currently, one of the most promising areas for using this drug is in the treatment of diabetic neuropathy.

About the Autors

Corresponding author: Irina A. Kurnikova, Dr. Sci. (Med.), Professor, Professor at the Department of Hospital Therapy with Courses in Endocrinology, Hematology and Clinical Laboratory Diagnostics, RUDN University, Moscow, Russia; curnikova@yandex.ru; ORCID: https://orcid.org/0000-0002-5712-9679; eLibrary SPIN: 8579-9455

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