Potential clinically significant drug interactions of drugs with green tea

DOI: https://dx.doi.org/10.18565/pharmateca.2021.10.111-116

A.P. Pereverzev (1), O.D., Ostroumova (1, 2), A.V. Filippova (1)

1) Russian Medical Academy for Continuing Professional Education, Moscow, Russia; 2) I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
No drug is absolutely safe, due to the risk of adverse drug reactions (ADRs). Serious ADRs that increase the risk of death or mortality and / or morbidity and / or require hospitalization are called drug-induced diseases. Often, drug-induced diseases can be prevented by adjusting modifiable risk factors including potential interactions with food (GT – for example green tea). GT has a complex chemical composition, including polyphenols (~30% dry weight), proteins (~15% dry weight), amino acids (~4% dry weight), dietary fiber (~26% dry weight), carbohydrates (~7% dry weight), fats (~7% dry weight), pigments (~2% dry weight), minerals (~5% dry weight). Polyphenolic compounds in PP contain many catechins, including epigallocatechin-3-gallate (EGCG), epicatechin-3-gallate, epicatechin and epigallocatechin. The content of EGCG in the GT is associated with various types of drug interactions. Also, methylxanthines (including caffeine) and purine alkaloids contained in the GT can interact with drugs. This article provides an overview of open literature sources on the pharmacodynamic and pharmacokinetic types of interactions between drugs and components of GT.
Keywords: drugs, adverse drug reactions, drug-induced diseases, drug-food interactions, green tea

About the Autors

Corresponding author: Olga D. Ostroumova, Dr. Sci. (Med.), Professor, Head of the Therapy and POLYMORBID Pathology Department, Russian Medical Academy of Continuous Professional Edu-cation; Professor of the Department of Clinical Pharmacology and Propedeutics of Internal Diseases, 
I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia; os-troumova.olga@mail.ru 
Address: build. 1, 2/1 Barrikadnaya St., Moscow 125993, Russian Federation

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