Antibiotic resistance of campylobacteria in St. Petersburg


DOI: https://dx.doi.org/10.18565/pharmateca.2021.1.76-80

K.D. Ermolenko (1), T.V. Potapova (2, 3)

1) Children’s Research and Clinical Center for Infectious Diseases FMBA of Russia, St. Petersburg, Russia; 2) Pavlov University, St. Petersburg, Russia; 3) S.P. Botkin Clinical Hospital for Infectious Diseases, Saint Petersburg, Russia
Background. Campylobacter is the leading hemorrhagic colitis and one of the most common bacterial infections in all regions of the world. In the extensive practice of practical medicine, the appointment of antibacterial drugs for campylobacteriosis is considered. This is of particular importance in the growing amount of data on the increased resistance of campylobacter to antimicrobial effects and the rapid spread of resistant strains in food and the environment.
Objective. Evaluation of the antibiotic resistance level of Campylobacter spp.
Material and methods. 50 patients with manifest forms of campylobacteriosis were examined. The phenotypic profiles of antibiotic resistance of 54 strains of Campylobacter jejuni and Campylobacter coli isolated from patients with manifest forms of the disease were studied. The sensitivity of the isolated strains to 10 antimicrobial drugs of 8 pharmacological groups (erythromycin, ciprofloxacin, nalidixic acid, gentamicin, amikacin, tetracycline, doxycycline, ampicillin, chloramphenicol, and cefotaxime) was determined by the disc diffusion method. Results. Most of the tested Campylobacter spp. strains were resistant to nalidixic acid and tetracycline. The frequency of isolation of strains resistant to macrolides and fluoroquinolones was 11.1 and 16.7%, respectively; 14.8% of isolates were multiresistant to 4 or more antibiotics. The obtained data indicate a high prevalence of antibiotic-resistant strains among campylobacteria isolated from patients with manifest forms of the disease. According to the study, risk factors for infection with resistant strains of Campylobacter spp. Included overseas travel to the Asian region and eradication therapy.
Conclusion. The results of the study confirm the need for further evaluation of the formation of antibiotic resistance of Campylobacter spp. based on the determination of genetic profiles and intracellular mechanisms of expression of other pathogenic factors.
Keywords: Campylobacter spp., antibiotic resistance, campylobacteriosis

About the Autors


Corresponding author: Konstantin D. Ermolenko, Cand. Sci. (Med.), Researcher at the Department of Intestinal Infections, Pediatric Research and Clinical Center for Infectious Diseases, St. Petersburg, Russia; e-mail: ermolenko.kd@yandex.ru; ORCID: https://orcid.org/0000-0002-1730-8576 
Address: 9 Professor Popov St., St. Petersburg 197022, Russian Federation


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