Evaluation of RET mRNA expression in malignant tumors of the salivary glands


DOI: https://dx.doi.org/10.18565/pharmateca.2019.12.56-58

S.I. Kutukova (1, 2), E.N. Imyanitov (3), Yu.V. Ivaskova (1, 2), N.P. Belyak (1, 4), A.Ya. Razumova (2)

1) City Clinical Oncology Dispensary, St. Petersburg, Russia; 2) Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia; 3) N.N. Petrov National Medical Research Center of Oncology, St. Petersburg, Russia; 4) St. Petersburg State University, Medical Faculty, St. Petersburg, Russia
Background. Treatment of locally advanced, recurrent or metastatic forms of malignant tumors of the salivary gland is a difficult task for clinical oncologists. Tumors of the salivary glands are insensitive to radiation and drug therapy.
Objective. Evaluation of the frequency of RET mRNA expression in malignant tumors of the salivary glands as a possible prognostic factor for the course of the disease.
Methods. The source of mRNA was archived pathological morphological samples of tumor tissue. Evaluation of mRNA expression of the RET kinase domain was performed using real-time polymerase chain reaction.
Results. RET expression was detected in 13 of 48 cases, which amounted to 27.08% of the examined tumors (in other words, in almost one third of the examined samples). The expression level ranged from 0 to 0.205.
Conclusion. The results obtained suggest that the RET mRNA expression level can be used not only as a prognostic, but also a predictive factor of the effectiveness of the multi-kinase inhibitors in this cohort of patients (after conducting prospective randomized trials).
Keywords: malignant tumors of the salivary glands, RET proto-oncogene expression

About the Autors


Corresponding author: Svetlana I. Kutukova, PhD, Oncologist, Chemotherapy Department (№ 11), City Clinical Oncology Dispensary; Associate Professor, Department of Surgical Dentistry and Maxillofacial Surgery, Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia; e-mail: dr.s.kutukova@gmail.com
Address: 56, Veteranov Avenue, St. Petersburg, 198255, Russian Federation


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