NEW METHOD OF DIFFERENTIAL DIAGNOSTICS OF UROGENITAL REACTIVE AND PSORIATIC ARTHRITIS
F.N. Paleev (1), Yu.V. Molochkova (2), M.S. Petrova (2)
1 National Medical Research Center for Cardiology, Moscow, Russia;
2 Moscow Regional Scientific Research Clinical Institute n.a. M.F. Vladimirsky, Moscow, Russia
The article presents the results of a examination of bioptates of lesions of 20 patients with stage II urgegenital reactive arthritis (UReA) and 40 patients with advanced psoriatic arthritis (PsA). The results of the histological examination indicated that there was no difference in the pattern of inflammation in both diseases, and there were no significant differences in immunoglobulin (Ig) deposits of different classes and the direct immunofluorescence (DIF) of lesions. However, using DIF method in UReA, IgG depositions of a diffuse nature were detected in the papillary and reticular dermis, and in PsA IgG deposits were detected only in the papillary dermis. It is also reported about the disappearance of IgG deposits in apparently healthy skin after the successful treatment of UReA. The obtained data on the important role of immune disorders in the pathogenesis of UReA and PsA, in particular about the significant differences in the nature of IgG deposits in the apparently healthy skin of these patients, can be used in the diagnosis and differential diagnosis of UReA and the possibility of using this method to evaluate the effectiveness of treatment of this disease.
Keywords: urogenital reactive arthritis, psoriasis, psoriatic arthritis, immunomorphological examination of the skin, direct immunofluorescence
About the Autors
Corresponding author: M.S. Petrova – Researcher at the Department of Dermatovenereology and Dermatooncology, Moscow Regional Scientific Research Clinical Institute n.a. M.F. Vladimirsky, Moscow, Russia; tel. +7 (499) 408-10-51, e-mail: firstname.lastname@example.org