ETIOLOGY OF ENDOMETRITIS AFTER CESAREAN SECTION AND ASSESSMENT OF EFFECTIVENESS OF ANTIBACTERIAL PREPARATIONS IN VITRO


DOI: https://dx.doi.org/10.18565/pharmateca.2018.6.55-59

N.N. Korbkov (1), Т.S. Barinova (2)

1 Department of Women’s Reproductive Health, North-Western State Medical University n.a. I.I. Mechnikov, Saint-Petersburg, Russia; 2 Maternity Hospital № 13, St. Petersburg, Russia
Background. For rational antibacterial therapy of postpartum endometritis, it is important to choose the right drug based on the local sensitivity of the pathogen to antibiotics. Objective. Evaluation of the etiological structure of endometritis after cesarean section and identification of the most effective antibacterial drugs based on in vitro studies. Methods. Bacteriological study of metoaspirate with determination of antibiotic susceptibility of obtained isolates in 70 puerperas with postpartum endometritis. Results. The microbiological studies have revealed that conditionally pathogenic microorganisms inhabiting the gastrointestinal tract (enterobacteria and enterococci) were predominantly isolated. Their proportion was 44%. In 15% of cases, the cause of metroendometritis was Staphylococcus aureus and Streptococci. In general, the isolated flora had a low resistance to the antibiotics most often used in maternity hospitals. Only a small number of strains had multiple drug resistance. Conclusion. Beta-lactam antibiotics remain the most effective drug in the treatment of endometritis after cesarean section.

About the Autors


Corresponding author: N.A. Korobkov – Associate Professor at the Department of Women’s Reproductive Health, North-Western State Medical University n.a. I.I. Mechnikov, St. Petersburg; e-mail nikolai_korobkov@mail.ru, ORCID: https://orcid.org/0000-0001-7279-2535


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