BIOLOGICAL EFFECTS OF GLYPROLINES MELANOCORTIN SERIES


DOI: https://dx.doi.org/10.18565/pharmateca.2018.5.26-30

A.E. Denisova (1), I.B. Filippenkov (2), V.V. Stavchansky (2), L.V. Dergunova (2), S.A. Limborska (2), L.V. Gubsky (3)

1) Department of Neurology, Neurosurgery and Medical Genetics, Pirogov Russian National Research Medical University, Moscow, Russia; 2) Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia; 3) Research Institute of Cerebrovascular Pathology and Stroke, Pirogov Russian National Research Medical University, Moscow, Russia
One of the main tasks in the field of biology and medicine is the creation of new pharmacologically powerful drugs with a wide spectrum of action and minimal side effects on the body. Currently, a class of regulatory peptides – gliprolins of the melanocortin series –
is actively studied; the main features of these peptides include the multidirectional action, the absence of side effects, and the ability of their metabolites to exert independent biological effects. This article summurizes the most relevant literature data on the properties of the following peptides: MGHPhPGP (Me-Glu-His-Phe-Pro-Gly-Pro), PGP (Pro-Gly-Pro), and PGPL (Pro-Gly-Pro-Leu).

About the Autors


Corresponding author: A.E. Denisova – Department of Neurology, Neurosurgery and Medical Genetics at the Pirogov RNRMU, Moscow, Russia; e-mail: dalina543@gmail.com


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