DIFFERENTIAL DIAGNOSTICS OF LUNG INJURY IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND ANTIPHOSPHOLIPIDIC SYNDROME: CLINICAL OBSERVATION


DOI: https://dx.doi.org/10.18565/pharmateca.2018.s2.62-67

E.A. Belolipetskaya (1), I.B. Belyaeva (1), V.I. Mazurov (1), O.V. Inamova (2), M.S. Petrova (2), E.A. Mozharovskaya (2)

1) North-Western State Medical University n.a. I.I. Mechnikov, Saint-Petersburg, Russia; 2) Clinical Rheumatological Hospital № 25, St. Petersburg, Russia
Background. In systemic lupus erythematosus (SLE), lung injury is not uncommon and requires therapy with cytostatics and glucocorticosteroids. With high clinical and immunological activity of SLE, an immunodeficiency state occurs, and the risk of infectious diseases, incl. tuberculosis, is increased. Description of the clinical case. A clinical case of a female patient with an interstitial lung injury is presented; differential diagnostics between tuberculous lesion and lung injury in SLE was performed. The importance of determination of the leading disease in connection with fundamentally different approaches to therapy for lupus pneumonitis and pulmonary tuberculosis is discussed. Conclusion. Lung injury in SLE in a patient with tuberculosis can cause diagnostic difficulties. Given the difference in tactics of treatment of SLE patients depending on the presence of comorbidities, immunosuppressive therapy in controversial situations should be prescribed with care.
Keywords: systemic lupus erythematosus, tuberculosis, antiphospholipid syndrome, computed tomography, color mapping

About the Autors


Corresponding author: E.A. Belolipetskaya – Postgraduate Student at the Department of Therapy and Rheumatology NWSMU n.a. I.I. Mechnikov, Rheumatologist at CRH № 25, St. Petersburg, Russia; e-mail: lisa_osutina@list.ru


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