ENTEROSORPTION IN THE TREATMENT OF DUODENAL ULCER IN CHILDREN IN THE SETTINGS OF HELICOBACTER PYLORI INFECTION AND CANDIDA COLONIZATION


DOI: https://dx.doi.org/10.18565/pharmateca.2018.2.79-82

T.G. Malanicheva, N.V. Ziatdinova

Kazan State Medical University, Kazan, Russia
Purpose of the study. To study the clinical endoscopic effectiveness of Enterosgel as a part of the standard treatment of Helicobacter pylori (Hp) – positive peptic duodenal ulcer (PDU) associated with fungi of the genus Candida in children. Material and methods. The prospective, controlled, randomized, open, single-site study included 55 children aged from 7 to 18 years with Hp-positive PDU associated with Candida fungi. Of them, 30 patients (the main group) received Enterosgel in an age-appropriate dose for 14 days in addition to standard therapy. In the comparison group, 25 children were subjected exclusively to the standard therapy. Results of the study. In the main group, where patients received Enterosgel additionally to the standard therapy, the overall therapeutic effect was 87% versus 72% in the comparison group. Besides, exacerbations were less severe and their duration was reduced by 28% with complete endoscopic remission on the background of negative results of culture mycological examination of the biopsy specimens of the mucous membrane of the duodenum, and the level of circulating candidiasis antibodies was decreased to trace amounts. Conclusion. The results of the study open up new possibilities for the use of Enterosgel in the treatment of children with Hp-positive PDU associated with fungi of the genus Candida.
Keywords: duodenal ulcer, Helicobacter pylori, Candida, Enterosgel, children

About the Autors


Corresponding author: T.G. Malanicheva – MD, Prof. at the Department of Propaedeutics of Children’s Diseases and Faculty Pediatrics with the Course of Children’s Diseases of the Medical Faculty of Kazan State Medical University, Kazan, Russia; tel. 8 (843) 268-58-21, e-mail: tgmal@mail.ru


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