POTENTIALS FOR THE CORRECTION OF DYSLIPIDEMIA IN PATIENTS WITH ARTERIAL HYPERTENSION


A.S. Ermolaeva, O.V. Dralova, PhD in Medical Sciences, O.D. Ostroumova, MD, M.L. Maksimov, MD

Department of Clinical Pharmacology and Propaedeutics of Internal Diseases SBEI HPE "First MSMU n.a. I.M. Sechenov" of RMPH, Moscow
The article presents the results of evaluation of antihypertensive and lipid-lowering effectiveness of combined antihypertensive therapy using angiotensin converting enzyme (ACE) inhibitor fosinopril in the starting dose of 10 mg/day, thiazide diuretic indapamide at the starting dose of 1.5 mg/day in combination with diet or with the addition of simvastatin. It is shown that the combination therapy in patients with dyslipidemic hypertension using ACE inhibitor and a statin can significantly reduce the risk of cardiovascular events. Despite equal antihypertensive effect, combination of fosinopril and simvastatin was significantly more effective compared to therapy with fosinopril in reducing the risk of major cardiovascular complications. Enhancement of clinical effect with the combination of ACE inhibitors and statins can be explained, most likely, not by the synergism of antihypertensive or lipid-lowering effects, but the synergistic angioprotective action.

About the Autors


A.S. Ermolaeva – postgraduate student at the Department of Clinical Pharmacology and Propaedeutics of Internal Diseases of the Medical Faculty SBEI HPE "First MSMU n.a. I.M. Sechenov" of RMPH
O.V. Dralova – PhD in Medical Sciences, Teaching Assistant at the Department of Clinical Pharmacology and Propaedeutics of Internal Diseases of the Medical Faculty SBEI HPE "First MSMU n.a. I.M. Sechenov" of RMPH; e-mail: olgadralova@rambler.ru
O.D. Ostroumova – MD, Prof. at the Department of Clinical Pharmacology and Propaedeutics of Internal Diseases SBEI HPE "First MSMU n.a. I.M. Sechenov" of RMPH
M.L. Maksimov – MD, Prof. at the Department of Clinical Pharmacology and Propaedeutics of Internal Diseases SBEI HPE "First MSMU n.a. I.M. Sechenov" of RMPH


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