Современные представления о микробиоме влагалища и его значении в патогенезе бактериального вагиноза


DOI: https://dx.doi.org/10.18565/pharmateca.2023.8.27-34

Малова И.О., Афанасьева И.Г.

Кафедра дерматовенерологии и косметологии, Иркутский государственный медицинский университет, Иркутск, Россия
Женское репродуктивное здоровье тесно связано со здоровой микробиотой влагалища. Это обеспечивается доминированием определенных видов Lactobacillus. Состояние вагинального микробиома до конца не изучено. Это связано в т.ч. с его эволюционной уникальностью. Животные модели имеют нейтральный рН, в их микробиомах не доминируют лактобактерии, а концентрация влагалищного гликогена и молочной кислоты значительно уменьшена. В связи с этим экспериментальные данные противоречивы и сложны для интерпретации in vivo. Определение основных механизмов, ответственных за стабильность вагинальной экониши, имеет большое значение. Представляется интересным посмотреть на бактериальный вагиноз через призму современных знаний о влагалищном микробиоме. В наших знаниях существуют пробелы в понимании изменчивости и взаимосвязей микробиоты влагалища.

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Об авторах / Для корреспонденции


Автор для связи: Ирина Геннадьевна Афанасьева, к.м.н., доцент кафедры дерматовенерологии и косметологии, Иркутский государственный медицинский университет, клиника кожных болезней, Иркутск, Россия; irishaaf@yandex.ru


ORCID:
И.Г. Афанасьева (I.G. Afanasyeva), https://orcid.org/0000-0001-5425-2826 
И.О Малова (I.O. Malova), https://orcid.org/0000-0002-5078-1955 


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